This semester, the antihypertensive effects of drugs that act on the renin-angiotensin system eg. AT1 receptor antagonists or directly on the heart and vasculature eg. calcium channel blockers. Currently these drugs can be co-administered with other antihypertensive classes including diuretics to improve the treatment of hypertension.

The clinical guidelines that prescribers use to select the appropriate medicines for individual patients are based on evidence from multiple clinical trials.

In this assignment you will examine the basic concepts of design, methodology and analysis of clinical trial data using an exemplar clinical trial focusing on antihypertensive medicines

In your article you should clearly explain

The pharmacology of Angiotensin receptor antagonists (ARBs) and Calcium Channel Blockers including their therapeutic use in the treatment of hypertension. (this section should be no more than 2-3 paragraphs)

A summary of the design and results from the clinical trial that compares the efficacy Valsartan and Amlodipine in the treatment of hypertension1.

Demonstrate a comprehensive understanding of the theory and application of Clinical Trial Design including (You will read the CONSORT 2010 paper and access and summarize further reference articles to competently complete this section).

 

  • inclusion and exclusion criteria,
  • randomisation of patients
  • minimization of bias
  • Kaplan-Meier plots
  • Hazards ratios

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