The cytoskeleton is more than just a structure that statically gives a cell its shape and strength. Cytoskeletal dynamics are crucial both during developmental wiring of the brain and in maintaining the adult brain. Outline some of these functions and how cytoskeletal-associated proteins including molecular motors, microtubule- and actin- associated proteins serve to regulate the proper functioning of the cytoskeleton during development of the brain and in synaptic function. How are some of these functions disrupted in disease? By what mechanism do molecular cellular defects underlie clinical phenotypes?

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